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Effect of intravenous diazepam on renal function.
Clinical Pharmacology and Therapeutics
|October 1, 1975
Summary
Intravenous diazepam transiently reduced kidney function, specifically glomerular filtration rate and renal plasma flow, in children and rabbits. This effect warrants consideration in patients with kidney issues or undergoing renal clearance tests.
Area of Science:
- Pharmacology
- Nephrology
- Anesthesiology
Background:
- Diazepam is a commonly used anxiolytic and sedative.
- Its effects on renal function, particularly in specific patient populations, require further elucidation.
Purpose of the Study:
- To investigate the impact of intravenous diazepam on glomerular filtration rate (GFR) and effective renal plasma flow (ERPF).
- To assess potential renal effects in pediatric patients and anesthetized rabbits.
Main Methods:
- GFR was measured using inulin clearance.
- ERPF was assessed via para-aminohippuric acid (PAH) clearance.
- Studies were conducted in 6 children and 12 anesthetized rabbits following intravenous diazepam administration.
Main Results:
- A transient decrease in both inulin clearance (GFR) and PAH clearance (ERPF) was observed in children receiving 4 mg of diazepam intravenously.
- Similar transient reductions in renal function and systemic arterial pressure occurred in anesthetized rabbits.
- Continuous infusion of diazepam did not alter renal function in rabbits.
Conclusions:
- Intravenous diazepam can transiently impair renal function.
- Caution is advised when administering diazepam to patients undergoing renal clearance studies or those with pre-existing renal insufficiency.