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Satiety: a graded behavioural phenomenon regulating caloric intake
Science (New York, N.Y.)
|October 10, 1975
Summary
Rhesus monkeys precisely regulate calorie intake by adjusting feeding behavior after nutrient preloads. This control is dose-dependent on calories, not volume or nutrient type, ensuring consistent energy consumption.
Area of Science:
- Physiology
- Animal Behavior
- Nutritional Science
Background:
- Organisms regulate energy intake to maintain metabolic homeostasis.
- Understanding nutrient sensing mechanisms is crucial for metabolic research.
Purpose of the Study:
- To investigate the precise mechanisms by which rhesus monkeys control caloric intake.
- To determine if caloric intake regulation is independent of preload volume, concentration, or nutrient composition.
Main Methods:
- Rhesus monkeys were administered intragastric nutrient preloads of varying volumes and caloric densities.
- Feeding behavior and subsequent caloric intake were monitored and analyzed.
- Dose-response relationships between preload calories and feeding inhibition were established.
Main Results:
- Monkeys demonstrated a significant inhibition of feeding in response to intragastric preloads.
- A clear dose-response relationship was observed, linking preload calories to feeding suppression.
- Caloric intake regulation was independent of preload volume, caloric concentration, and nutrient type.
- Effective caloric control was maintained even with residual preload in the stomach.
Conclusions:
- Rhesus monkeys possess a sophisticated system for regulating caloric intake.
- Caloric intake is accurately controlled based on energy content, irrespective of preload characteristics.
- This study highlights the sensitivity of nutrient sensing mechanisms in primates.
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