Related Experiment Video
Updated: Sep 13, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
Published on: January 24, 2016
Interferon regulatory factor 7: a key cellular mediator of LMP-1 in EBV latency and transformation
1Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7295, USA. luzhang@med.unc.edu
Abstract:
Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein-Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.
Related Concept Videos
Negative Regulator Molecules
Non-LTR Retrotransposons
Master Transcription Regulators
Abnormal Proliferation
Inhibitors of Viral Protein Synthesis
Inhibitors Of Virion Release

