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Summary
Methenamine gel stick effectively reduced excessive sweating in hyperhidrosis patients. This safe topical treatment offered prolonged relief for many, even those with formaldehyde sensitivity.
Area of Science:
- Dermatology
- Clinical Pharmacology
Background:
- Essential hyperhidrosis is a condition characterized by excessive sweating.
- Topical treatments are a common therapeutic approach for managing hyperhidrosis.
Purpose of the Study:
- To evaluate the efficacy and safety of a methenamine gel stick formulation for treating essential hyperhidrosis.
- To assess the duration of relief after treatment discontinuation.
Main Methods:
- A double-blind, placebo-controlled study was conducted on 26 individuals with essential hyperhidrosis.
- Participants were treated with a methenamine gel stick formulation.
- Efficacy was measured by the reduction in palmar and plantar sweating.
Main Results:
- Methenamine gel stick significantly decreased sweating in 24 out of 26 participants.
- One patient with a confirmed formaldehyde sensitivity tolerated the treatment well.
- Approximately one-third of patients reported sustained relief for 1-3 weeks post-treatment.
Conclusions:
- Methenamine gel stick is a safe and effective topical therapy for essential hyperhidrosis.
- The formulation offers a promising new option for patients seeking relief from excessive sweating.
- Extended relief was observed even after cessation of the topical treatment.