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Total Synthesis of (-)-Reserpine Using the Chiron Approach
Stephen Hanessian1, Jingwen Pan, Andrew Carnell
1Department of Chemistry, Université de Montréal, P. O. Box 6128, Station Centreville, Montréal, QC, Canada H3C 3J7.
The Journal of Organic Chemistry
|February 7, 1997
Abstract:
A highly stereocontrolled synthesis of ring D/E precursor to reserpine has been developed starting from (-)-quinic acid as a chiral template. The total synthesis of (-)-reserpine is described through the cyclization of an immonium lactam intermediate.