Jove
Visualize
Contact Us

Related Experiment Videos

Solid-Phase Synthesis of beta-Sultams.

Mikhail F. Gordeev1, Eric M. Gordon, Dinesh V. Patel

  • 1Affymax Research Institute, 3410 Central Expressway, Santa Clara, California 95051.

The Journal of Organic Chemistry
|October 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A New and Efficient Solid Phase Synthesis of Hydroxamic Acids.

The Journal of organic chemistry·2001
Same journal

Concise Synthesis of Pyrano/Benzopyrano[2,3-<i>c</i>]pyrazol-6-ones via Ir/Rh-Catalyzed C-H Activation and Tandem Annulation.

The Journal of organic chemistry·2026
Same journal

Regiodivergent Cyclizations of Donor-Acceptor Cyclopropanes with Hydrazines under Solventless, Mechanochemical Milling.

The Journal of organic chemistry·2026
Same journal

Photocatalytic Decarboxylative Coupling of Diacyl Peroxides with TEMPO.

The Journal of organic chemistry·2026
Same journal

Mechanistic Insights into the Isothiourea-Catalyzed Addition Reaction of a <i>para</i>-Nitrophenyl Ester and an <i>N</i>-Benzylpyridinium Salt.

The Journal of organic chemistry·2026
Same journal

Catalytic, Regioselective Hydrocarbofunctionalization of Unactivated Alkenes with Anthrones and 9-Phenanthrols.

The Journal of organic chemistry·2026
Same journal

Copper(II)-Catalyzed <i>N</i>-Arylation and <i>N</i>-Vinylation of Oxadiazolones with Boronic Acids under Mild Conditions.

The Journal of organic chemistry·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

A new solid-phase synthesis method enables the creation of beta-sultam combinatorial libraries. This approach facilitates the discovery of novel antibacterial agents by generating diverse sulfonyl beta-lactam analogues.

Area of Science:

  • Organic Chemistry
  • Medicinal Chemistry
  • Synthetic Chemistry

Background:

  • Beta-sultams are sulfur-containing heterocyclic compounds with potential biological activity.
  • Combinatorial chemistry approaches are crucial for drug discovery, enabling the rapid synthesis of diverse compound libraries.
  • Solid-phase synthesis offers advantages in purification and automation for library generation.

Purpose of the Study:

  • To develop a novel solid-phase synthesis strategy for beta-sultams.
  • To create sulfonyl beta-lactam analogue combinatorial libraries.
  • To facilitate the identification of new antibacterial agents.

Main Methods:

  • Solid-phase synthesis utilizing polymer-immobilized amino acids and aldehydes.
  • Reaction of imine intermediates with (chlorosulfonyl)acetates in the presence of pyridine.

Related Experiment Videos

  • Cleavage of beta-sultam products from solid support using acidic (TFA) or photocleavage methods.
  • Further functionalization of immobilized beta-sultams to yield thiazetidine derivatives.

    • Main Results:

    • Successful solid-phase synthesis of beta-sultam intermediates.
    • Demonstration of facile cleavage from solid support via acid-labile or photolabile linkers.
    • Generation of diverse beta-sultam and thiazetidine derivatives.
    • Establishment of a method amenable for combinatorial library production.

    Conclusions:

    • The developed solid-phase synthesis is effective for constructing diverse beta-sultam libraries.
    • This method provides a platform for the discovery of novel antibacterial compounds.
    • The strategy allows for the generation of sulfonyl beta-lactam analogues for drug screening.