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Titanocene-Catalyzed Reduction of Lactones to Lactols
Xavier Verdaguer1, Marcus C. Hansen, Scott C. Berk
1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
The Journal of Organic Chemistry
|October 24, 2001
Abstract:
A convenient method for the conversion of lactones to lactols is described. The hydrosilylation to lactols is carried out via air-stable titanocene difluoride or a titanocene diphenoxide precatalyst using inexpensive polymethylhydrosiloxane (PMHS) as the stoichiometric reductant. These procedures have been demonstrated with a variety of substrates and proceed in good to excellent yield.