Related Experiment Videos
B-cell acute lymphoblastic leukemia with tandem t(14;14)(q11;q32)
R Berger1, M Busson, M T Daniel
1INSERM U 434, SDI 401 No.434 CNRS, Institut de Génétique Moléculaire, 27 rue Juliette Dodu, 75010, Paris, France. roland.berger@cephb.fr
Cancer Genetics and Cytogenetics
|October 24, 2001
Abstract:
Translocation (14;14)(q11;q32) was associated with acute lymphoblastic leukemia in a child. The B-cell lineage of the leukemic cells led us to perform FISH studies, which showed that the chromosomal breakpoints were telomeric to TCRA/D and IGH loci. These findings show that FISH analyses are necessary when unusual features are associated with a recurrent translocation.