Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Making mitochondrial mutants.

H T Jacobs1

  • 1Institute of Medical Technology and Tampere University Hospital, FIN-33014 University of Tampere, Tampere, Finland. howy.jacobs@uta.fi

Trends in Genetics : TIG
|October 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heteroplasmic segregation associated with trisomy-9 in cultured human cells.

Somatic cell and molecular genetics·2004
Same author

Prominent mitochondrial DNA recombination intermediates in human heart muscle.

EMBO reports·2001
Same author

Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility.

Nature genetics·2001
Same author

Technical knockout, a Drosophila model of mitochondrial deafness.

Genetics·2001
Same author

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.

Nature genetics·2001
Same author

Novel coding-region polymorphisms in mitochondrial seryl-tRNA synthetase (SARSM) and mitoribosomal protein S12 (RPMS12) genes in DFNA4 autosomal dominant deafness families.

Human mutation·2001
Same journal

The future of marsupial gene editing: What's in the (tool) pouch?

Trends in genetics : TIG·2026
Same journal

Genetic suppressors as new therapeutic targets for Mendelian diseases.

Trends in genetics : TIG·2026
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
Same journal

The myth of asexual fungi.

Trends in genetics : TIG·2026
See all related articles

Mitochondrial DNA (mtDNA) research is advancing, offering new ways to study its essential role in energy metabolism and human health. Genetic manipulation techniques are improving our understanding of mtDNA

Area of Science:

  • Genetics
  • Molecular Biology
  • Biochemistry

Background:

  • Mitochondrial DNA (mtDNA) encodes 13 essential polypeptides for cellular energy metabolism.
  • Despite being sequenced over two decades ago, the broader physiological roles of mtDNA remain incompletely understood.
  • The essential nature of mtDNA gene products and technical challenges in genetic manipulation have hindered research.

Purpose of the Study:

  • To address the limitations in understanding the physiological roles of mitochondrial DNA.
  • To explore the potential of recent advancements in mtDNA genetic manipulation.
  • To elucidate the contribution of mtDNA to human development, physiology, and disease.

Main Methods:

  • Review of current understanding of mtDNA gene products and their functions.

Related Experiment Videos

  • Discussion of historical and recent technical challenges and breakthroughs in mtDNA genetic engineering.
  • Exploration of the implications of mtDNA research for human health and disease.

    • Main Results:

    • Mitochondrial DNA's role in energy metabolism is well-defined but its wider physiological significance is less clear.
    • Genetic manipulation of mtDNA has been technically challenging, limiting research.
    • Recent technical developments are beginning to enable genetic manipulation of mtDNA.

    Conclusions:

    • Advancements in mtDNA genetic manipulation offer new avenues for research.
    • Understanding mtDNA's contribution to human development, physiology, and disease is becoming more attainable.
    • Further research is crucial to fully elucidate the complex roles of mitochondrial DNA.