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Updated: Aug 6, 2026
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An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
Published on: December 7, 2016
Transscleral drug delivery for posterior segment disease
1Department of Ophthalmology, Emory Eye Center, Suite B2600, 1365B Clifton Road, NE, Atlanta, GA 30322, USA.
Advanced Drug Delivery Reviews
|October 24, 2001
Summary
New treatments for retinal degeneration face delivery challenges. Transscleral delivery shows promise for effectively reaching posterior eye tissues, improving drug concentration for treating posterior segment eye diseases.
Area of Science:
- Ophthalmology
- Pharmacology
- Biomedical Engineering
Background:
- Retinal degenerations and posterior segment eye diseases are visually devastating conditions.
- Current treatments are limited by the difficulty of delivering drugs to target tissues in the posterior eye (vitreous, retina, choroid).
Purpose of the Study:
- To review recent laboratory and clinical studies on transscleral drug delivery.
- To assess the potential of transscleral delivery for treating posterior segment eye diseases.
Main Methods:
- Review of existing laboratory and clinical research.
- Analysis of studies investigating transscleral delivery of therapeutic agents.
Main Results:
- Transscleral delivery is a potential method for achieving therapeutic drug concentrations in the posterior segment of the eye.
- This approach may overcome current limitations in drug delivery for posterior eye diseases.
Conclusions:
- Transscleral delivery offers a promising strategy for treating retinal degenerations and other posterior segment eye conditions.
- Further research and clinical application of transscleral delivery could significantly improve patient outcomes.
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