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Updated: Aug 14, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

Solid-Phase Synthesis of 3,4,5-Substituted 1,5-Benzodiazepin-2-ones

Jung Lee1, Diane Gauthier, Ralph A. Rivero

  • 1The R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477.

The Journal of Organic Chemistry
|October 25, 2001
PubMed
Summary

A novel solid-phase synthesis enables efficient preparation of 3,4,5-substituted 8-carboxamido-1,5-benzodiazepin-2-ones. This method yields diverse benzodiazepine derivatives with high isolated yields, facilitating drug discovery.

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