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P(RNCH(2)CH(2))(3)N-Catalyzed Synthesis of beta-Hydroxy Nitriles
Philip Kisanga1, Dale McLeod, Bosco D'Sa
1Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111.
The Journal of Organic Chemistry
|October 25, 2001
Abstract:
We herein report the successful synthesis of beta-hydroxy nitriles in very good to excellent yields from aldehydes and ketones in a simple reaction that is promoted by strong nonionic bases of the title type. The reaction occurs in the presence of magnesium salts which activate the carbonyl group and stabilizes the enolate thus produced.