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Facile nitroxide-mediated oxidations of D-glucose to D-glucaric acid
N Merbouh1, J Francois Thaburet, M Ibert
1Department of Chemistry, University of Connecticut, Storrs 06269-3060, USA.
Carbohydrate Research
|October 25, 2001
Abstract:
The oxidation of D-(+)-glucose to D-glucaric acid using the TEMPO-like nitroxide oxidation catalyst, 4-acetamido-2,2,6,6-tetramethyl-1-piperidinyloxy (4-acetamido-TEMPO) was carried out using several oxidizing agents and co-catalyst. The pH and temperature of the reactions were closely monitored to decrease degradations during the oxidation, and several isolation methods were explored.