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Dynamic temporal and spatial regulation of the cdk inhibitor p57(kip2) during embryo morphogenesis
J Westbury1, M Watkins, A C Ferguson-Smith
1School of Biological Sciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK.
Mechanisms of Development
|October 26, 2001
Abstract:
The complete developmental expression pattern of the cyclin dependent kinase inhibitor (CDKI) p57(kip2) has not been reported, here we report a detailed study of the localization of p57(kip2) protein during mouse organogenesis. We show that p57(kip2) is coincident with key stages of differentiation of several organs, some but not all of which are affected in Beckwith-Weidermann syndrome, a human congenital syndrome characterized by foetal overgrowth and childhood tumours.