Related Experiment Videos
Chemokines in autoimmune disease
1Department of Pharmacology, Almirall Prodesfarma Research Center, Cardener 68-74, 08028, Barcelona, Spain. Ngodessa@almiralprodesfarma.com
Current Opinion in Immunology
|October 26, 2001
Summary
Structural cells recruit immune cells via chemokines, driving chronic autoimmune inflammation. Targeting these chemokines may offer new therapies for autoimmune diseases.
Area of Science:
- Immunology
- Autoimmunity
- Cell Biology
Background:
- Chronic inflammation in autoimmune diseases involves structural cells.
- Chemokines (chemoattractant cytokines) are key mediators in immune cell recruitment.
- Both inflammatory and homeostatic chemokines play roles in autoimmune pathogenesis.
Purpose of the Study:
- To investigate the role of chemokines in autoimmune inflammation.
- To explore chemokines as potential therapeutic targets in autoimmunity.
Main Methods:
- Review of evidence on chemokine function in autoimmune diseases.
- Analysis of findings from animal models of autoimmunity.
Main Results:
- Structural cells recruit chemokine-dependent cells, contributing to chronic inflammation.
- Chemokines regulate lymphocyte recruitment, survival, and ectopic lymphoid structure formation in target organs.
- Animal models indicate the therapeutic potential of targeting chemokines.
Conclusions:
- Chemokines are critical players in the development and progression of autoimmune diseases.
- Targeting chemokines presents a promising therapeutic strategy for managing autoimmunity.