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Published on: January 20, 2015
Fipronil-based photoaffinity probe for Drosophila and human beta 3 GABA receptors
N S Sirisoma1, G S Ratra, M Tomizawa
1Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, USA.
Bioorganic & Medicinal Chemistry Letters
|October 26, 2001
Abstract:
Modification of the major insecticide fipronil (1) by replacing three pyrazole substituents (hydrogen for both cyano and amino and trifluoromethyldiazirinyl for trifluoromethylsulfinyl) gives a candidate photoaffinity probe (3) of high potency (IC(50) 2-28 nM) in blocking the chloride channel of Drosophila and human beta 3 GABA receptors.
