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Prognostic indicators of local recurrence in patients operated for rectal cancer
G B Secco1, G Ravera, P Bonfante
1DICMI, Sezione di Semeiotica Chirurgica I, University of Genoa School of Medicine, Genoa, Italy.
Background/Aims:
To identify subgroups of patients at high risk of local relapse after curative surgery for rectal cancer.
Methodology:
Thirty-five variables of 216 patients observed from January 1987 to December 1995 were retrospectively analyzed according to univariate and multivariate methods. Median follow-up was 38 months.
Results:
High and moderate grade (P = 0.0001), Size > or = 5 cm (P = 0.013), lymph nodes involvement (P = 0.002) and patients with locally advanced rectal cancer underwent extensive surgery and postoperative radiation significantly increased local relapse; whereas surgical procedure and experience of surgeons had no influence.
Conclusions:
The above-mentioned prognostic factors of rectal cancer that show a risk of local relapse 2- to 3.5-times higher than comparative conditions could be useful in identifying subgroups of patients at high risk for local recurrence. These patients should undergo a careful selection according to risk factors of relapse in order to increase local control of disease performing "optimal" primary surgery, effective postoperative radiation and tailored follow-up.