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Spontaneous closure of ventricular septal defects in the first year of life

M H Lin1, N K Wang, K L Hung

  • 1Department of Pediatrics, Cathay General Hospital, 360, Section 2, Nei-Hu Road, Taipei, Taiwan.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|October 27, 2001
PubMed

Insights

Ventricular septal defects (VSD) were found in 21.3/1,000 neonates. Muscular VSDs showed higher spontaneous closure rates than perimembranous VSDs within the first year.

Area of Science:

  • Pediatric Cardiology
  • Neonatal Health
  • Congenital Heart Defects

Background:

  • Increased prevalence of Ventricular Septal Defect (VSD) linked to improved echocardiography and screening.
  • Need to understand spontaneous closure rates for different VSD types in neonates.

Purpose of the Study:

  • Determine the prevalence of VSD in neonates.
  • Evaluate the timing and likelihood of spontaneous closure for specific VSD types (muscular vs. perimembranous).

Main Methods:

  • Echocardiographic screening of 3,472 clinically normal neonates.
  • Follow-up evaluation of VSD outcomes during the first year of life.
  • Categorization of VSDs into muscular, perimembranous, and subpulmonic types.

Main Results:

  • VSD prevalence was 21.3 per 1,000 live births (74 neonates).
  • Muscular VSDs (48) were more common than perimembranous VSDs (25).
  • Overall spontaneous closure rate reached 73% by 12 months; muscular defects closed more readily than perimembranous ones.

Conclusions:

  • Neonatal VSD prevalence is 21.3/1,000 live births.
  • Muscular VSDs are the most common type and demonstrate a higher probability of spontaneous closure.
  • Most muscular VSDs close spontaneously within the first year of life.
Abstract

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