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The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus
A S Ratnayake1, W Y Yoshida, S L Mooberry
1Department of Chemistry, University of Hawaii, 2545 McCarthy Mall, Honolulu, Hawaii 96822, USA.
Organic Letters
|October 27, 2001
Abstract:
[structure: see text]. A new alkyl-substituted nonenolide, microcarpalide 1, has been isolated from fermentation broths of an unidentified endophytic fungus. Microcarpalide is weakly cytotoxic to mammalian cells and acts as a microfilament disrupting agent. The structure of 1 was elucidated by application of spectroscopic methods. The absolute configuration was determined by the exciton chirality method.