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Synthetic studies toward gambierol. Convergent synthesis of the octacyclic polyether core
H Fuwa1, M Sasaki, K Tachibana
1Department of Chemistry, Graduate School of Science, The University of Tokyo, and CREST, Japan Science and Technology Corporation, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Organic Letters
|October 27, 2001
Abstract:
[structure: see text]. A convergent synthetic route to the octacyclic polyether core of gambierol, a marine polycyclic ether toxin, has been developed. The synthesis involves construction of two fragments representing the ABC and EFGH ring systems followed by their coupling via a B-alkyl Suzuki reaction.