Related Experiment Video
Updated: Aug 19, 2026

Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
Published on: January 16, 2013
Quality of life is impaired in men with chronic prostatitis: the Chronic Prostatitis Collaborative Research Network
M McNaughton Collins1, M A Pontari, M P O'Leary
1General Medicine Unit, Medical Services, Massachusetts General Hospital, Boston, MA 02114, USA. mmcnaughtoncollins@partners.org
Insights
Men with chronic prostatitis experience significant mental and physical health-related quality of life (HRQOL) impairment. Understanding these impacts is crucial for optimizing patient care.
Area of Science:
- Urology
- Public Health
- Psychosomatic Medicine
Background:
- Chronic prostatitis significantly impacts men's health-related quality of life (HRQOL).
- Understanding factors associated with HRQOL impairment is essential for effective management.
Purpose of the Study:
- To examine HRQOL in men with chronic prostatitis.
- To identify factors associated with both general and condition-specific HRQOL impairments.
Main Methods:
- The study involved 278 men with chronic prostatitis across six research centers in the US and Canada.
- Health-related quality of life was assessed using the Short Form 12 (SF-12) and the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI).
Main Results:
- Chronic prostatitis patients exhibited lower Mental Component Summary (MCS) and Physical Component Summary (PCS) scores compared to general populations and severe disease subgroups.
- Worsening symptom severity correlated with decreased MCS and PCS scores.
- Psychiatric history and younger age were linked to poorer MCS, while rheumatologic disease history was associated with worse PCS and higher NIH-CPSI scores. Lower education and income predicted more severe NIH-CPSI scores.
Conclusions:
- Men with chronic prostatitis suffer from impaired general and condition-specific HRQOL.
- Clinicians should utilize HRQOL instruments to better assess and address the patient's condition and its impact on their lives.
Objective:
Health-related quality of life (HRQOL) impairment may be a central component of chronic prostatitis for men afflicted with this condition. Our objective was to examine HRQOL, and factors associated with HRQOL, using both general and condition-specific instruments.
Design:
Chronic Prostatitis Cohort (CPC) study.
Setting:
Six clinical research centers across the United States and Canada.
Participants:
Two hundred seventy-eight men with chronic prostatitis.
Measurements And Main Results:
The Short Form 12 (SF-12) Mental Component Summary (MCS) and Physical Component Summary (PCS), and the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) were measures used. CPC subjects' MCS scores (44.0 +/- 9.8) were lower than those observed in the most severe subgroups of patients with congestive heart failure and diabetes mellitus, and PCS scores (46.4+/-9.5) were worse than those among the general U.S. male population. Decreasing scores were seen in both domains with worsening symptom severity (P < .01). History of psychiatric disease and younger age were strongly associated with worse MCS scores, whereas history of rheumatologic disease was associated with worse PCS scores. Predictors of more severe NIH-CPSI scores included lower educational level and lower income; history of rheumatic disease was associated with higher scores.
Conclusions:
Men with chronic prostatitis experience impairment in the mental and physical domains of general HRQOL, as well as condition-specific HRQOL. To optimize the care of men with this condition, clinicians should consider administering HRQOL instruments to their patients to better understand the impact of the condition on patients' lives.
Related Concept Videos
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Nursing Assessment of the Genitourinary System I: Health History
Chronic Kidney Disease III: Interprofessional Care

