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Development of a neuronal pressure sensor.

R D Heal¹, A T Rogers, G G Lunt

¹BioPhysics Research Group, Defence Evaluation and Research Agency (Winfrith), Dorchester, Dorset DT2 8XJ, UK. rdheal@dera.gov.uk

Biosensors & Bioelectronics

|October 27, 2001

Summary

Researchers created an in vitro neuronal network from rat neurons that exhibits rhythmic firing patterns. This biological sensor

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Area of Science:

Neuroscience
Biotechnology
Sensor Technology

Background:

Neuronal sensory systems possess complex signal processing capabilities.
Reconstructing these systems in vitro could lead to novel biological sensors.
Developing whole-cell biological sensors with inherent signal processing is a key goal.

Purpose of the Study:

To present preliminary investigations into creating a mechanosensory neuronal network in vitro.
To explore the potential of neuronal networks for biological sensing applications.

Main Methods:

An in vitro network of rat dorsal root ganglion neurons was established on a microelectrode plate.
The spontaneous electrical activity of the neuronal network was recorded.
The effect of static pressure on the network's activity was observed.

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Main Results:

A rhythmical pattern of spontaneous neuronal discharges was observed in the in vitro network.
Application of static pressure disrupted this periodic activity.
These findings demonstrate the network's responsiveness to mechanical stimuli.

Conclusions:

Neuronal networks can be cultured in vitro to exhibit functional properties.
These networks show potential as a basis for intelligent, whole-cell, biological sensors.
The mechanosensory properties observed suggest applications in pressure sensing.