[Nasosinusal sarcoidosis: 13 cases]

Area of Science:

• Medicine
• Pathology
• Otolaryngology

Background:

• Sarcoidosis is a systemic inflammatory disease characterized by non-caseating granulomas.
• Nasosinusal involvement in sarcoidosis is uncommon, occurring either in isolation or alongside systemic manifestations.
• Understanding the clinical presentation and diagnostic challenges of nasosinusal sarcoidosis is crucial.

Purpose of the Study:

• To describe the clinical and imaging features of nasosinusal sarcoidosis.
• To evaluate diagnostic methods and treatment outcomes for this rare condition.
• To highlight the variability in disease course and treatment response.

Main Methods:

• Retrospective case series analysis of 13 patients with nasosinusal sarcoidosis.
• Review of clinical data, imaging findings (CT scans), and histopathological results.
• Assessment of treatment strategies, including corticosteroid therapy, and patient outcomes.

Main Results:

• Nasosinusal sarcoidosis presented with diverse and often non-specific clinical and CT findings.
• Nasal biopsy, guided by physical examination, was the primary diagnostic tool.
• Treatment with corticosteroids showed variable responses, with frequent recurrences upon dose reduction or cessation, and significant side effects.

Conclusions:

• Nasosinusal sarcoidosis is a rare entity with varied presentations, necessitating biopsy for definitive diagnosis.
• Current treatment strategies, primarily corticosteroids, offer variable efficacy and are associated with frequent relapses and adverse effects.
• Further research is needed to establish standardized treatment protocols for nasosinusal sarcoidosis.