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Chromatographic detection of captopril using 4-dimethylaminobenzaldehyde as spray reagent
1Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
Bollettino Chimico Farmaceutico
|October 30, 2001
Abstract:
Thin layer chromatographic method, using a mixture of acetone:ethanol in the ratio of 9:1 as a developing solvent system, was used to detect captopril in its formulation. The developed chromatogram was sprayed with 4-dimethylaminobenzaldehyde. The product formed by reaction of captopril with 4-dimethylaminobenzaldehyde gave a yellow colour. Rf of captopril is 0.56.