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[Intravenous multi vitamin formulation to use in pediatric total parenteral nutrition]

P Carreño1, A Rosas, I Rojas

  • 1Escuela de Química y Farmacia, Universidad de Valparaíso, Hospital Dr Gustavo Fricke, Viña del Mar, Chile. patricia.carreno@uv.cl

Revista Medica De Chile
|October 30, 2001
PubMed

Insights

A new parenteral multivitamin solution for pediatric patients was developed, offering a stable, safe, and cost-effective alternative. This formulation meets pediatric nutritional needs, unlike adult versions previously used in Chile.

Area of Science:

  • Pharmaceutical Sciences
  • Pediatric Nutrition
  • Formulation Development

Context:

  • Chilean market lacks specific intravenous multivitamin formulations for pediatric patients.
  • Adult multivitamin formulations are currently used, potentially not meeting pediatric requirements.
  • Total parenteral nutrition (TPN) in pediatrics necessitates appropriate vitamin supplementation.

Purpose:

  • To develop and characterize a stable, aqueous parenteral multivitamin solution suitable for pediatric patients.
  • To ensure the formulation meets quality control standards including organoleptic, microbiologic, and pyrogen testing.
  • To assess the compatibility and stability of the vitamin solution within TPN formulae.

Summary:

  • A new parenteral multivitamin solution was successfully prepared and formulated for pediatric use.
  • Quality control confirmed the absence of microbial contamination and pyrogens, with stability for one month at 4°C.
  • The formulation demonstrated compatibility with TPN solutions and was found to be cost-effective.

Impact:

  • Provides a safe and effective multivitamin option for pediatric patients requiring TPN.
  • Offers significant cost savings compared to using adult formulations.
  • Addresses a critical unmet need in the Chilean pediatric healthcare market.
Abstract

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