Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The neurohypophysis.

G Valiquette1

  • 1Helen Hayes Hospital, West Haverstraw, New York 10993, USA.

Neurologic Clinics
|May 1, 1987
PubMed
Summary

This review explores vasopressin (VP) and oxytocin (OT) beyond their traditional roles. New findings suggest VP impacts blood pressure and hypertension, while OT

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Saxagliptin efficacy.

Diabetes, obesity & metabolism·2010
Same author

Desmopressin in the management of nocturia in patients with multiple sclerosis. A double-blind, crossover trial.

Archives of neurology·1996
Same author

DDAVP in the management of nocturia in multiple sclerosis.

Annals of neurology·1992
Same author

Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy.

Science (New York, N.Y.)·1989
Same author

Monoclonal antibodies: uses in studies on vasopressin.

Methods in enzymology·1989
Same author

Immunocytochemical study of the development of vasotocin/mesotocin in the hypothalamo-hypophysial system of the chick embryo.

Cell and tissue research·1986

Area of Science:

  • Neuroendocrinology
  • Physiology
  • Pathophysiology

Background:

  • Vasopressin (VP) and oxytocin (OT) are neurohypophysial hormones with established roles in water balance, parturition, and lactation.
  • Traditional views limit VP to antidiuretic hormone (ADH) functions, overlooking its potent vasoactive properties.
  • Existing literature lacks a clear distinction for cases of SIADH with normal VP secretion control.

Purpose of the Study:

  • To explore novel physiological and pathophysiological aspects of vasopressin (VP) and oxytocin (OT).
  • To review the dual role of VP as an antidiuretic hormone and a pressor peptide.
  • To propose a new classification for specific cases of SIADH.

Main Methods:

  • Literature review of current research on VP and OT physiology and pathophysiology.
  • Analysis of evidence linking VP to blood pressure regulation and hypertension.
  • Examination of clinical presentations of diabetes insipidus and SIADH.

Main Results:

  • VP exhibits significant pressor activity, suggesting a role in blood pressure maintenance and potentially hypertension.
  • Evidence indicates VP's involvement in cardiovascular regulation beyond water balance.
  • The review highlights the need to differentiate SIADH with normal VP secretion control, proposing the term SAADH (syndrome of appropriate secretion of vasopressin).

Conclusions:

  • Vasopressin (VP) plays a crucial role in blood pressure regulation and may be implicated in hypertension.
  • Oxytocin (OT) roles in parturition and lactation are reviewed, with new evidence suggesting fetal involvement in labor initiation.
  • Distinguishing between abnormal VP secretion control (SIADH) and normal control (SAADH) is critical for accurate diagnosis and management.

Related Experiment Videos