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HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other
T Tasara1, G Maga, M O Hottiger
1Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Zurich, Switzerland.
FEBS Letters
|October 30, 2001
Abstract:
Ordered molecular interactions and structural changes must take place within the human immunodeficiency virus type 1 (HIV-1) preintegration complex at various stages for successful viral replication. We demonstrate both physical and biochemical interactions between HIV-1 reverse transcriptase and integrase enzymes. This interaction may have implications on the in vivo functions of the two enzymes within the HIV-1 replication complex. It may be one of the various molecular interactions, which facilitate efficient HIV-1 replication within the target cells.