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Related Experiment Videos

Lateral and oblique gene transfer.

H Ochman1

  • 1Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721-0088, USA. hochman@email.arizona.edu

Current Opinion in Genetics & Development
|October 30, 2001
PubMed
Summary
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Large-scale bacterial genome analysis reveals extensive gene transfer and exchange. While often uncoupled, gene exchange can be low in some species, yet pathogenic strains acquire virulence factors via lateral gene transfer.

Area of Science:

  • Microbiology
  • Evolutionary Biology
  • Genomics

Background:

  • Complete genome sequencing and multi-locus strain analysis are revolutionizing bacterial evolution studies.
  • Large-scale genomic assessments reveal widespread gene transfer and exchange in bacteria.

Purpose of the Study:

  • To investigate the relationship between gene transfer and exchange in bacterial evolution.
  • To understand the mechanisms driving the emergence of pathogenic bacterial strains.

Main Methods:

  • Comparative genomics of complete bacterial genomes.
  • Analysis of genetic variation across multiple loci within bacterial species.

Main Results:

  • Evidence for extensive horizontal gene transfer and genetic exchange across bacterial species.

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  • Gene transfer and exchange are generally uncoupled processes.
  • Species like Escherichia coli exhibit limited gene exchange.
  • Pathogenic strain emergence is linked to lateral gene transfer of virulence factors.

    • Conclusions:

    • Genomic data provides unprecedented insights into bacterial evolution.
    • Lateral gene transfer plays a critical role in bacterial adaptation and pathogenicity.