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Risk factors for preterm premature rupture of membranes at Mulago Hospital, Kampala
1Department of Obstetrics and Gynaecology, Makerere University Medical School, P.O. Box 7072, Kampala, Uganda.
Objective:
To evaluate the epidemiological risk factors in patients admitted at Mulago Hospital with preterm premature rupture of the membranes from their socio-demographic characteristics and reproductive history.
Design:
Cross-sectional case control study.
Setting:
Labour ward, Mulago Hospital, Kampala, Uganda.
Methods:
Cases were enrolled at admission while controls were enrolled after a term delivery not preceded by pre-mature rupture of the membrane (PROM). Controls were matched for age range (age +/- 2 years) and parity with the cases. A detailed history of socio-demographic characteristics, past medical and surgical illness and past reproductive history were obtained and data entered into a coded questionnaire. Endocervical swabs and amniotic fluid samples were taken from the cases during labour. Validity was assessed using Chi-square with a p-value of less than 0.05 considered significant.
Results:
Maternal socio-demographic characteristics were similar for cases and controls. A history of hypertension, abortion, prior PROM, Caesarean section, cervical cerclage, cervical incompetence or abnormal vaginal discharge were significant risk factors for preterm PROM (p < 0.05).
Conclusion:
There are factors by which mothers at risk of preterm PROM can be identified before onset of rupture.
