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Updated: Oct 3, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
Published on: November 21, 2025
Nerve blocks in chronic pain therapy--are there any indications left?
1Division of Anesthesiology for Pain Management and Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Abstract:
Although diagnostic imaging is now highly developed, neural blockade provides another opportunity to test for a source of pain that may frequently leave no signature. Likewise, many neuropathic pains can not be tested by neurodiagnostic methods. This paper makes a case for the continued use of regional anesthesia to assist in the diagnosis and therapy of chronic pain. In particular, the example of autonomic blocks and blocks of the axial spine are emphasized. Nerve blocks require an understanding of the anatomy, physiology, pharmacology, and the ability to interpret critically their results.
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