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Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system.

T R Clandinin¹, C H Lee, T Herman

¹Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, School of Medicine, CA 90095, USA.

|October 31, 2001

Summary

LAR, a receptor tyrosine phosphatase, is crucial for Drosophila photoreceptor neuron targeting specificity. LAR mutations disrupt correct connections in the optic lobe, impacting R cell axon guidance.

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Area of Science:

Neuroscience
Developmental Biology
Genetics

Background:

Photoreceptor neurons (R cells) in the Drosophila compound eye exhibit precise targeting within the optic lobe.
Establishing correct neuronal connections is vital for visual processing and circuit function.

Purpose of the Study:

To identify genetic factors regulating R cell target specificity in Drosophila.
To investigate the role of LAR, a receptor tyrosine phosphatase, in R cell axon guidance.

Main Methods:

Behavioral screening to identify genes involved in R cell targeting.
Generation of LAR mutant mosaic eyes in Drosophila.
Analysis of R cell axon projection patterns using microscopy and mosaic analysis.

Main Results:

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Dissection and Immunohistochemistry of Larval, Pupal and Adult Drosophila Retinas

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LAR is essential for R cell target specificity in the Drosophila optic lobe.
Mutations in LAR lead to aberrant targeting of R1-R6 and R7 photoreceptor neurons.
LAR controls R cell targeting in a cell-autonomous manner, similar to N-cadherin.

Conclusions:

LAR plays a critical cell-autonomous role in ensuring accurate R cell innervation of target neurons.
LAR function in target specificity is conserved with N-cadherin, suggesting shared molecular mechanisms.