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Glucose hypometabolism gates tau-dependent necroptosis
Maria Livia Sassano1, Bart De Strooper2
1Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium; Center for Neuroscience Leuven, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.
Neuron
|September 2, 2026
Abstract:
Tau pathology closely tracks neuronal loss in Alzheimer's disease, but how phosphorylated tau becomes lethal has remained unclear. Chen et al. identify a dual-hit mechanism: glucose hypometabolism removes a protective A20-mediated brake on necroptosis while phosphorylated tau scaffolds RIPK1 activation, driving tau-associated neuronal death.1.
