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Updated: May 2, 2026

Transcranial Pulse Stimulation for Alzheimer's Patients
Published on: April 4, 2025
Tracking the turning point in Alzheimer's disease.
Bart De Strooper1,2,3, Henrik Zetterberg3,4,5
1Leuven Brain Institute, University of Leuven, Leuven, Belgium.
A novel blood biomarker indicates a shift in Alzheimer's disease mechanisms, moving from amyloid plaque buildup to tau protein tangles. This discovery offers new insights into disease progression and potential therapeutic targets.
Area of Science:
- Neuroscience
- Biochemistry
- Biomarker Discovery
Background:
- Alzheimer's disease is characterized by amyloid plaques and tau tangles.
- Understanding the transition between these pathologies is crucial for effective treatment.
Purpose of the Study:
- To identify a blood biomarker that reflects the shift from amyloid to tau pathology in Alzheimer's disease.
- To elucidate the mechanistic changes occurring during disease progression.
Main Methods:
- Development and validation of a novel blood assay.
- Analysis of patient samples to correlate biomarker levels with pathological markers.
Main Results:
- A specific blood biomarker was identified that accurately indicates a shift in pathological dominance from amyloid to tau.
- The biomarker shows potential for monitoring disease progression and therapeutic response.
Conclusions:
- Blood biomarkers can reveal dynamic changes in Alzheimer's disease pathology.
- This finding opens new avenues for non-invasive diagnosis and tracking of Alzheimer's disease progression.
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