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Neuroactive steroids modulate crustacean locomotor activity.

M J Snyder1, H V Peeke

  • 1Bodega Marine Laboratory, University of California, P.O. Box 247, 2099 Westside Road, Bodega Bay, CA 94923, USA. mjsnyder@ucdavis.edu

Neuroscience Letters
|October 31, 2001
PubMed
Summary
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Neuroactive steroids impact lobster movement. Allopregnanolone reduced activity, while pregnenolone sulfate increased it, suggesting similar GABA receptor functions across species.

Area of Science:

  • Neuroscience
  • Marine Biology
  • Endocrinology

Background:

  • Neuroactive steroids modulate gamma-aminobutyric acid(A) (GABA)(A) receptor activity.
  • GABA(A) receptors are crucial in regulating neuronal excitability and behavior in vertebrates.
  • The role of neuroactive steroids in invertebrate behavior, particularly in crustaceans, is less understood.

Purpose of the Study:

  • To investigate the effects of specific neuroactive steroids on locomotor activity in the American lobster (Homarus americanus).
  • To determine if neuroactive steroids interact with crustacean GABA receptors in a manner analogous to vertebrate GABA(A) receptors.
  • To explore the involvement of neuroactive steroids in the regulation of crustacean locomotor behavior.

Main Methods:

  • Juvenile male lobsters were treated with either an agonist (3alpha-hydroxy-5alpha-pregnan-20-one, 3alpha,5alpha-TH PROG), an antagonist (pregnenolone sulfate, PREGS), or a vehicle control.

Related Experiment Videos

  • Locomotor activity was measured in a submerged circular open-field apparatus.
  • Dose-dependent effects of the neuroactive steroids on activity levels and patterns were analyzed.

    • Main Results:

    • 3alpha,5alpha-TH PROG significantly reduced locomotor activity at doses of 125 and 250 microg.
    • PREGS significantly elevated locomotor activity in a dose-dependent manner at lower doses (30 and 60 microg).
    • At a higher dose (120 microg), PREGS diminished locomotor activity and altered movement patterns.

    Conclusions:

    • Neuroactive steroids, specifically allopregnanolone and pregnenolone sulfate, exert significant effects on lobster locomotor activity.
    • These findings suggest that crustacean GABA receptors may be modulated by neuroactive steroids similarly to vertebrate GABA(A) receptors.
    • Neuroactive steroids are likely involved in the regulation of locomotor behavior in crustaceans, indicating conserved neurochemical pathways.