Related Experiment Videos
Hypoxia: the tumor's gateway to progression along the angiogenic pathway
C Brahimi-Horn1, E Berra, J Pouysségur
1Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A. Lacassagne, 33 Avenue Valombrose, 06189 Nice, France. brahimi@unice.fr
Trends in Cell Biology
|October 31, 2001
Abstract:
Decreased aerobic (hypoxic) conditions in tumors induce the release of cytokines that promote vascularization and thereby enhance tumor growth and metastasis. Recent major advances have provided insight into the role hypoxia plays in cancer biology. The domain structure of the hypoxia-inducible factor 1alpha (HIF-1alpha) has been elucidated, as has the mechanism by which stabilization of HIF-1alpha leads to initiation of the transcription of target genes involved in growth of blood vessels.