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Assessment of thyroid function during pregnancy.

V Chan, C A Paraskevaides, J F Hale

    British Journal of Obstetrics and Gynaecology
    |February 1, 1975
    PubMed
    Summary
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    Thyroid stimulating hormone levels remain stable during pregnancy. Measuring urinary thyroid hormone excretion offers a simple method for assessing thyroid function in pregnant individuals.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Clinical Chemistry

    Background:

    • Thyroid hormones are crucial for maternal and fetal health.
    • Pregnancy-induced physiological changes can affect thyroid hormone levels.
    • Accurate assessment of thyroid function during pregnancy is essential.

    Purpose of the Study:

    • To compare thyroid hormone levels in pregnant and non-pregnant women.
    • To evaluate the reliability of different thyroid function tests during pregnancy.
    • To identify the simplest and most effective method for assessing thyroid function in pregnant individuals.

    Main Methods:

    • Comparison of serum levels of thyroid stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3).
    • Assessment of serum protein binding capacity.

    Related Experiment Videos

  • Measurement of urinary T3 and T4 excretion.

    • Main Results:

    • Serum TSH levels showed no significant alteration throughout pregnancy.
    • Total serum T4 and T3 concentrations increased significantly during the first and second trimesters.
    • Increased thyroid hormone levels correlated with increased thyroid binding capacity of serum proteins.
    • Urinary T3 and T4 excretion in the third trimester was comparable to non-pregnant controls.

    Conclusions:

    • Thyroid stimulating hormone levels are stable during pregnancy.
    • Urinary thyroid hormone excretion provides a simple and reliable method for assessing thyroid function in pregnant women.
    • This method is recommended for clinical practice during pregnancy.