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Related Experiment Videos

Thromboelastography: a reliable test?

S Vig1, A Chitolie, D H Bevan

  • 1Department of Vascular Surgery, St George's Hospital, London, UK. svig@doctors.org.uk

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|October 31, 2001
PubMed
Summary
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The thromboelastograph (TEG) shows initial sample instability up to 30 minutes. After 30 minutes, TEG provides stable and reproducible results for assessing haemostasis, crucial for clinical applications.

Area of Science:

  • Clinical diagnostics
  • Haemostasis and thrombosis research

Background:

  • The thromboelastograph (TEG) is vital for optimizing blood product use in surgery.
  • Its potential for screening hypercoagulable states is under investigation.
  • Concerns exist regarding TEG's consistency and result validity due to limited performance data.

Purpose of the Study:

  • To evaluate the impact of blood sample stability on TEG testing.
  • To assess variability in repeated sampling, intra-assay, and inter-assay measurements.
  • To analyze TEG performance with native, celite, tissue factor (TF), and Reopro modifications.

Main Methods:

  • Investigated blood sample stability for up to 90 minutes.
  • Performed repeated assays on the same samples.
  • Assessed intra- and inter-assay variability for different TEG modifications.

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Main Results:

  • Native and celite TEG samples exhibited instability within the first 30 minutes.
  • TEG parameters remained stable between 30 and 90 minutes post-sampling (P=NS).
  • Repeated native and celite TEG assays showed significant hypercoagulability changes (P<0.01), unlike TF and Reopro modifications.
  • Intra- and inter-assay variability were excellent for samples tested after 30 minutes (P=NS).

Conclusions:

  • Thromboelastography (TEG) is a valuable tool for haemostasis assessment.
  • A standardized operating procedure is essential, accounting for initial sample instability.
  • Optimized TEG protocols can ensure reliable results for clinical decision-making.