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Related Experiment Videos

Ocular surface changes induced by contact lens wear.

P J Pisella1, F Malet, S Lejeune

  • 1Department of Ophthalmology, CHU de Tours, France.

Cornea
|October 31, 2001
PubMed
Summary

Contact lens wearers show subclinical conjunctival inflammation, with soft contact lenses (SCL) causing more inflammation than rigid contact lenses (RCL). Mucin levels decrease in both contact lens groups over time.

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Area of Science:

  • Ophthalmology
  • Cell Biology
  • Biomaterials Science

Background:

  • Contact lens (CL) wear is common, but can induce ocular surface changes.
  • Subclinical inflammation and altered mucus production are potential consequences.
  • Understanding these changes is crucial for CL wearer eye health.

Purpose of the Study:

  • To evaluate subclinical conjunctival inflammation and mucus production in asymptomatic contact lens wearers.
  • To compare inflammation and mucus levels between rigid CL (RCL) and soft CL (SCL) wearers.
  • To assess chronologic variations in these parameters.

Main Methods:

  • Impression cytology (IC) was used to collect conjunctival specimens.
  • Flow cytometry analyzed inflammatory markers (HLA DR, ICAM-1) and mucin (M1/MUC5AC).

Related Experiment Videos

  • Specimens from 18 eyes (RCL), 28 eyes (SCL), and 10 control eyes were compared.

    • Main Results:

    • Soft CL wearers showed significantly higher levels of HLA DR and ICAM-1 compared to controls.
    • Mucin levels (M1/MUC5AC) significantly decreased in both CL groups.
    • Inflammation patterns varied over time, with generally lower levels in RCL wearers.

    Conclusions:

    • Asymptomatic CL wearers exhibit distinct subclinical conjunctival inflammation.
    • Rigid CL wear is associated with lower inflammation levels than soft CL wear.
    • Chronic ocular surface stress from CL wear modifies the mucin system, leading to decreased expression over time.