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Updated: Aug 10, 2026
Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections
Published on: November 14, 2016
The major histocompatibility complex of the rat (Rattus norvegicus)
1Abteilung Immungenetik, Universität Göttingen, Heinrich-Düker-Weg 12, 37073 Göttingen, Germany. eguenth@gwdg.de
Abstract:
This review of the RT1 complex, the major histocompatibility complex (MHC) of the rat, focuses on genetic, genomic, evolutionary, and functional aspects at the molecular level. The class I, class II, and framework genes are listed. The physical map of the RT1 complex as revealed by analysis of clonal contigs is compared with the human and mouse MHC, and the degree of orthologous relationship is outlined. Elucidation of the RT1 complex provides important information for using the rat as a model of experimental transplantation and complex diseases.
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