Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between Leishmania parasites and host cells.

O Brandonisio1, M A Panaro, M Sisto

  • 1Dipartimento di Clinica Medica, Immunologia e Malattie Infettive, Sezione di Microbiologia e Immunologia, Università di Bari, Policlinico, Piazza G. Cesare, 70124 Bari, Italy. brandoni@cimedoc.uniba.it

Parassitologia
|November 1, 2001
PubMed
Summary

Leishmania parasites evade host immunity by inhibiting crucial cell signaling pathways. Understanding these mechanisms, like protein kinase C inhibition, is key to developing new treatments for leishmaniasis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Probiotics may modulate the impact of aging on adults.

Journal of biological regulators and homeostatic agents·2020
Same author

Interleukin-17 and -22 synergy linking inflammation and EMT-dependent fibrosis in Sjögren's syndrome.

Clinical and experimental immunology·2019
Same author

Idiopathic sudden sensorineural hearing loss and ménière syndrome: The role of cerebral venous drainage.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2017
Same author

Downstream activation of NF-κB in the EDA-A1/EDAR signalling in Sjögren's syndrome and its regulation by the ubiquitin-editing enzyme A20.

Clinical and experimental immunology·2016
Same author

Transcatheter closure of an unligated vertical vein with an Amplatzer Vascular Plug-II device.

Journal of cardiovascular medicine (Hagerstown, Md.)·2014
Same author

The Concise Guide to PHARMACOLOGY 2013/14: overview.

British journal of pharmacology·2014

Area of Science:

  • Immunology
  • Parasitology
  • Molecular Biology

Background:

  • Leishmania protozoa cause human visceral and cutaneous diseases.
  • Transmission occurs via sandflies, with parasites residing in macrophages.
  • Host defense relies on T helper 1 cells, interferon-gamma, and nitric oxide.

Purpose of the Study:

  • To investigate Leishmania's immune evasion strategies.
  • To understand parasite inhibition of host cell signaling pathways.
  • To explore potential therapeutic targets for leishmaniasis.

Main Methods:

  • Studies in murine models of Leishmania major infection.
  • Analysis of host-parasite interactions at the molecular level.
  • Evaluation of signaling pathway modulation by Leishmania.

Related Experiment Videos

Main Results:

  • Leishmania inhibits protein kinase C activation and Ca++ influx.
  • Parasites block interferon-gamma-induced tyrosine kinase phosphorylation.
  • Leishmania activates protein phosphotyrosine phosphatases, down-regulating key signaling pathways.

Conclusions:

  • Leishmania employs sophisticated mechanisms to evade host immune responses by disrupting signal transduction.
  • Inhibition of signaling pathways impairs macrophage activation and parasite killing.
  • Targeting protein tyrosine phosphatases and farnesyltransferases shows promise for leishmaniasis treatment.