Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive dysfunction lateralizes with NAA in multiple sclerosis.

J W Pan1, L B Krupp, L E Elkins

  • 1Medical Department, Brookhaven National Laboratory, Upton, New York, USA.

Applied Neuropsychology
|November 1, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaging the Internal Auditory Canal with an 8 × 2 Transceiver Array Head Coil at 7T.

AJNR. American journal of neuroradiology·2025
Same author

Should Age 65 be a cutoff for Primary Progressive Multiple Sclerosis therapy? Real World Data is Critical.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2023
Same author

Common Neurologic Features of Lyme Disease That May Present to a Rheumatologist.

Pathogens (Basel, Switzerland)·2023
Same author

[Pelvic loose body: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2020
Same author

Remotely-delivered cognitive remediation in multiple sclerosis (MS): protocol and results from a pilot study.

Multiple sclerosis journal - experimental, translational and clinical·2017
Same author

Therapy Optimization in Multiple Sclerosis: a cohort study of therapy adherence and risk of relapse.

Multiple sclerosis and related disorders·2015
Same journal

Demographic and injury-related moderators of memory and achievement outcome in pediatric TBI.

Applied neuropsychology·2011
Same journal

Validation of WAIS-III four-subtest short forms in patients with traumatic brain injury.

Applied neuropsychology·2011
Same journal

Sensitivity of the test of memory malingering and the Nonverbal Medical Symptom Validity Test: a replication study.

Applied neuropsychology·2011
Same journal

An investigation of impaired scores on the frontal assessment battery in a VA population.

Applied neuropsychology·2011
Same journal

Characteristic of cognitive decline in Parkinson's disease: a 1-year follow-up.

Applied neuropsychology·2011
Same journal

Rehearsal significantly improves immediate and delayed recall on the Rey Auditory Verbal Learning Test.

Applied neuropsychology·2011
See all related articles

Magnetic resonance spectroscopic imaging reveals correlations between brain N-acetyl aspartate (NAA) levels and cognitive function in multiple sclerosis (MS) patients. This technique may offer a more comprehensive assessment of MS, beyond physical disability measures.

Area of Science:

  • Neuroimaging
  • Neurology
  • Cognitive Science

Background:

  • Multiple sclerosis (MS) assessment often overlooks cognitive impairments.
  • Current methods like the Expanded Disability Status Scale prioritize ambulation.
  • Cognitive deficits in memory and processing speed are prevalent in MS.

Purpose of the Study:

  • To investigate the relationship between cognitive function and N-acetyl aspartate (NAA) levels in MS patients.
  • To explore the utility of quantitative magnetic resonance (MR) spectroscopic imaging in assessing MS-related cognitive changes.
  • To determine if specific brain NAA concentrations correlate with performance on cognitive tests.

Main Methods:

  • Quantitative MR spectroscopic imaging was employed.
  • N-acetyl aspartate (NAA) concentrations were measured in periventricular (PV) regions.

Related Experiment Videos

  • Cognitive performance was assessed using the verbal Selective Reminding Test and the Tower of Hanoi.

    • Main Results:

    • A significant positive correlation was found between left PV NAA concentrations and verbal Selective Reminding Test performance (r = .63, p < .005).
    • Right PV NAA concentrations showed a significant correlation with Tower of Hanoi performance (r = .58, p < .02).

    Conclusions:

    • Quantitative MR spectroscopy, specifically NAA levels, shows promise for evaluating cognitive function in MS.
    • This neuroimaging approach may provide a more sensitive measure of disease impact than traditional scales.
    • MR spectroscopic imaging can help elucidate the neural underpinnings of cognitive deficits in multiple sclerosis.