Remotely-delivered cognitive remediation in multiple sclerosis (MS): protocol and results from a pilot study

Area of Science:

• Neuroscience
• Rehabilitation Medicine
• Digital Health

Background:

• Cognitive impairment is a significant challenge for individuals with multiple sclerosis (MS), impacting their quality of life.
• Traditional cognitive remediation requires frequent clinic visits, posing a barrier to consistent treatment.
• Computer-based interventions offer a promising avenue for remote, intensive, and personalized cognitive training.

Purpose of the Study:

• To develop and evaluate a protocol for remotely-supervised cognitive remediation for MS patients.
• To assess the feasibility of conducting a clinical study using a home-based cognitive training program.
• To maintain clinical study standards while enabling remote participation.

Main Methods:

• Twenty MS participants were randomized into an active cognitive remediation group (n=11) or a control group (n=9) using computer games.
• Participants completed 30 hours of training over 12 weeks on study-provided laptops, training 5 days/week.
• Cognitive and motor function changes were assessed using a repeated neuropsychological test battery.

Main Results:

• High compliance was observed, with participants completing an average of 25.0 hours (80% of target), with no significant difference between groups.
• The active cognitive remediation group showed significant improvements in cognitive measures (mean composite z-score change of 0.46).
• Participants in the active group also demonstrated significant improvements in motor tasks (mean composite z-score change of 0.40).

Conclusions:

• Remotely-supervised cognitive remediation is a feasible approach for clinical studies involving MS patients.
• This method shows potential for delivering meaningful cognitive and motor benefits to individuals with MS.
• Home-based, digitally delivered interventions can enhance treatment accessibility and adherence in MS care.