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Related Experiment Video

Updated: May 2, 2026

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Social cognition in pediatric-onset multiple sclerosis (MS).

L E Charvet1, R E Cleary2, K Vazquez2

  • 1Lourie Center for Pediatric Multiple Sclerosis, Department of Neurology, Stony Brook Medicine, USA leigh.charvet@stonybrookmedicine.edu.

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Summary

Children with pediatric-onset multiple sclerosis (MS) show deficits in social cognition, impacting their ability to understand social cues. These findings highlight the need for early intervention in pediatric MS patients.

Keywords:
Pediatriccognitionmultiple sclerosissocial cognitiontheory of mind

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Area of Science:

  • Neurology
  • Neuropsychology
  • Developmental Pediatrics

Background:

  • Pediatric-onset multiple sclerosis (MS) affects individuals during development.
  • Social cognitive deficits are known in adult MS patients.
  • Investigating these deficits in pediatric MS is crucial.

Purpose of the Study:

  • To determine if pediatric-onset MS is associated with social cognitive deficits.
  • To assess Theory of Mind (ToM) performance in children with MS.

Main Methods:

  • Compared pediatric MS patients (n=28) to age/gender-matched healthy controls (n=32).
  • Utilized Theory of Mind (ToM) tasks: Reading the Mind in the Eyes Test, Faux Pas Test, False Beliefs Task.
  • Assessed information processing speed using the Symbol Digit Modalities Test.

Main Results:

  • Pediatric MS patients performed significantly worse on all three ToM tasks compared to controls.
  • Impaired performance was observed in facial affect recognition, social faux pas detection, and perspective-taking.
  • Information processing speed deficits in MS patients did not explain the social cognition differences.

Conclusions:

  • Social cognition is a potential area of cognitive impairment in pediatric-onset MS.
  • Early identification of social cognitive deficits is vital for long-term social adjustment and well-being in young MS patients.