Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How smell develops.

P Mombaerts1

  • 1The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA. peter@rockefeller.edu

Nature Neuroscience
|November 1, 2001
PubMed
Summary
This summary is machine-generated.

Mice use about 1000 olfactory sensory neurons to smell. Each neuron picks one odor receptor gene and connects to a specific olfactory bulb glomerulus, but other factors also influence this wiring.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure and emergence of specific olfactory glomeruli in the mouse.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

The human repertoire of odorant receptor genes and pseudogenes.

Annual review of genomics and human genetics·2001
Same author

Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption.

Development (Cambridge, England)·2001
Same author

Efficient metaphase II transgenesis with different transgene archetypes.

Nature biotechnology·2001
Same author

Selective deletion of leptin receptor in neurons leads to obesity.

The Journal of clinical investigation·2001
Same author

Olfactory coding: revealing intrinsic representations of odors.

Current biology : CB·2001
Same journal

Neural timescales from a computational perspective.

Nature neuroscience·2026
Same journal

Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.

Nature neuroscience·2026
Same journal

Hippocampal theta sweeps indicate goal direction during navigation.

Nature neuroscience·2026
Same journal

Just how goal-directed are hippocampal theta sweeps, anyway?

Nature neuroscience·2026
Same journal

Goal-directed hippocampal theta sweeps during memory-guided navigation.

Nature neuroscience·2026
Same journal

Connectomic evidence that ordered activity drives neuromuscular network formation.

Nature neuroscience·2026
See all related articles

Area of Science:

  • Neuroscience
  • Olfactory system research
  • Sensory biology

Background:

  • The mammalian sense of smell relies on approximately 1000 input channels.
  • Each channel involves olfactory sensory neurons expressing a single odorant receptor gene.
  • These neurons project axons to specific targets called glomeruli in the olfactory bulb.

Purpose of the Study:

  • To investigate the mechanisms of odorant receptor gene choice.
  • To understand the process of axonal wiring in the olfactory system.
  • To clarify the determinants of glomerular targeting by olfactory sensory neurons.

Main Methods:

  • Genetic experiments were utilized to study gene choice and axonal projection.
  • Analysis of the relationship between odorant receptor expression and glomerular targeting.

Related Experiment Videos

  • Investigating the role of the expressed odorant receptor in specifying axonal choice.

    • Main Results:

    • A single neuron expresses one odorant receptor gene from a repertoire of approximately 1000.
    • Axons from neurons expressing the same receptor converge to the same glomerulus.
    • The expressed odorant receptor is a key determinant, but not the sole factor, in axonal wiring.

    Conclusions:

    • Odorant receptor gene choice and axonal wiring are fundamental to the olfactory system's organization.
    • While principles are emerging, a complete understanding of these mechanisms is still limited.
    • Further research is needed to fully elucidate the complex processes governing olfactory sensory neuron connectivity.