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Estrogen stimulation of conjugase activity in the uterus of ovariectomized rats
The American Journal of Clinical Nutrition
|May 11, 1975
Abstract:
Recent observations have indicated that uterine folic acid conjugase (pterolypolyglutamyl hydrolase) undergoes rhythmic variation during the reproductive cycle of the rat. In the present study conjugase activity and ratios of "total" folate to "free" folate were determined in uterine homogenates of ovariectomized rats, with ane without estrogen stimulation. An increase in conjugase levels and a relative increase in the "free" folate component occurred in castrated animals 12 to 18 hours following injection of 10 mug of estradiol-17beta.
Keywords:
Animals, LaboratoryBiologyClinical ResearchEndocrine SystemEstradiol--administraction and dosageEstradiol--side effectsEstrogens--administraction and dosageEstrogens--side effectsFamily PlanningFemale Sterilization--side effectsGenitaliaGenitalia, FemaleGynecologic SurgeryHematological EffectsHemic SystemHormonesOvariectomy--side effectsPhysiologyResearch MethodologySerum Folate LevelSterilization, SexualSurgeryTreatmentUrogenital SurgeryUrogenital SystemUterine EffectsUterus