What is a "clinically meaningful" reduction in pain?

Greater recalled pain and movement-evoked pain are associated with longer 400-m walk and repeat stair climb timein older adults: the study of muscle, mobility, and aging.

GeroScience·2026

Greater recalled pain and movement-evoked pain are associated with longer 400-meter walk and repeat stair climb time: the Study of Muscle, Mobility and Aging.

medRxiv : the preprint server for health sciences·2024

Methods for pragmatic randomized clinical trials of pain therapies: IMMPACT statement.

Pain·2024

Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement.

Pain·2023

Pitfalls and Rewards of Setting Up a Liquid Biopsy Approach for the Detection of Driver Mutations in Circulating Tumor DNAs: Our Institutional Experience.

Journal of personalized medicine·2022

Combination pharmacotherapy for the treatment of neuropathic pain in adults: systematic review and meta-analysis.

Pain·2022

One in seven has severe pain: a point-prevalence study of hospitalised patients across Africa.

Pain·2026

Methodological considerations for designing and conducting open-label placebo trials.

Pain·2026

Manual and automated capture of analgesic-responsive facial pain behaviors of unrestrained mice in a trigeminal neuralgia model.

Pain·2026

Emerging clinical pain research in low- and middle-income settings: towards a person-centred approach.

Pain·2026

Temporal contrast enhancement in auditory and nociceptive processing.

Pain·2026

A glutamatergic S1-VPL-S1 corticothalamocortical loop amplifies mechanical hypersensitivity in neuropathic pain.

Pain·2026

Ultrasound-Guided Supracondylar Radial Nerve Block Versus Hematoma Block for Closed Reductions of Distal Radius Fracture in the Emergency Department: A Randomized Controlled Clinical Trial.

Journal of hand surgery global online·2026

Liposomal bupivacaine surgical site injection for decrease of narcotic use in hip fractures: a pilot multicenter randomized trial.

OTA international : the open access journal of orthopaedic trauma·2026

Rapid Symptom Reduction Following Intramuscular Ketamine in Refractory Obsessive-Compulsive Disorder: A Case Report.

Case reports in psychiatry·2026

Initial conceptual development of a pilot questionnaire for patient-perceived clinical inertia in chronic disease management: an exploratory study with a predominantly Peruvian sample.

Frontiers in health services·2026

Complex regional pain syndrome research trends: A bibliometric analysis of the last 3 decades (1993-2025).

Medicine·2026

Postoperative Management After Penile Fracture Surgery: Intra-operative Drainage Is Not Associated With Early Morbidity Reduction (FRACT AFUF project).

The French journal of urology·2026

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What is a "clinically meaningful" reduction in pain?

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Greater recalled pain and movement-evoked pain are associated with longer 400-m walk and repeat stair climb timein older adults: the study of muscle, mobility, and aging.

Greater recalled pain and movement-evoked pain are associated with longer 400-meter walk and repeat stair climb time: the Study of Muscle, Mobility and Aging.

Methods for pragmatic randomized clinical trials of pain therapies: IMMPACT statement.

Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement.

Pitfalls and Rewards of Setting Up a Liquid Biopsy Approach for the Detection of Driver Mutations in Circulating Tumor DNAs: Our Institutional Experience.

Combination pharmacotherapy for the treatment of neuropathic pain in adults: systematic review and meta-analysis.

One in seven has severe pain: a point-prevalence study of hospitalised patients across Africa.

Methodological considerations for designing and conducting open-label placebo trials.

Manual and automated capture of analgesic-responsive facial pain behaviors of unrestrained mice in a trigeminal neuralgia model.

Emerging clinical pain research in low- and middle-income settings: towards a person-centred approach.

Temporal contrast enhancement in auditory and nociceptive processing.

A glutamatergic S1-VPL-S1 corticothalamocortical loop amplifies mechanical hypersensitivity in neuropathic pain.

Ultrasound-Guided Supracondylar Radial Nerve Block Versus Hematoma Block for Closed Reductions of Distal Radius Fracture in the Emergency Department: A Randomized Controlled Clinical Trial.

Liposomal bupivacaine surgical site injection for decrease of narcotic use in hip fractures: a pilot multicenter randomized trial.

Rapid Symptom Reduction Following Intramuscular Ketamine in Refractory Obsessive-Compulsive Disorder: A Case Report.

Initial conceptual development of a pilot questionnaire for patient-perceived clinical inertia in chronic disease management: an exploratory study with a predominantly Peruvian sample.

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