[Deep mycosis and lung tumor induced by dark-pigmented micromycetes]

The authors carried out an experiment on mice infected with dark-pigmented micromicetes Aspergillus clavitus and Exophiala dermatitidis, preplanted from lung operational material of patients with chronic non-specific lung disease and destructive tuberculosis. The infection was produced by the peroral method in the first group of animals and by the intranasal method in the second group. By day 30 the test animals developed mycotic sepsis, fifty percent of the animals had malignant lung growths (adenocarcinoma, squamous cell carcinoma and angiopericytoma). Established in the experiment was toxicity and cancerogenity of dark-pigmented micromicetes Aspergillus clavitus and Exophiala dermatitidis. A model of mycotic sepsis and micromicete-induced lung cancer has been created.