Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Classification of Illness

Classification of Illness

The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.

Nonlinear Pharmacokinetics: Causes of Nonlinearity

Nonlinear Pharmacokinetics: Causes of Nonlinearity

Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens.
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The impact of body mass index on Esophagectomy: perioperative and oncological outcomes.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2026

Same author

Alternative type 2 diabetes screening tests may reduce the number of U.S. adults with undiagnosed diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2020

Same author

Retinopathy develops at similar glucose levels but higher HbA<sub>1c</sub> levels in people with black African ancestry compared to white European ancestry: evidence for the need to individualize HbA<sub>1c</sub> interpretation.

Diabetic medicine : a journal of the British Diabetic Association·2020

Same author

Evaluation of a comprehensive diabetic foot ulcer care quality model.

Journal of diabetes and its complications·2020

Same author

Impact of mismatches in HbA<sub>1c</sub> vs glucose values on the diagnostic classification of diabetes and prediabetes.

Diabetic medicine : a journal of the British Diabetic Association·2019

Same author

Racial differences in performance of HbA<sub>1c</sub> for the classification of diabetes and prediabetes among US adults of non-Hispanic black and white race.

Diabetic medicine : a journal of the British Diabetic Association·2019

Same journal

Correction to I.M. Matters News: Sleep medicine for seniors.

Annals of internal medicine·2026

Same journal

Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone : A Target Trial Emulation.

Annals of internal medicine·2026

Same journal

Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-Like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026

Same journal

Methodological Approaches to Real-World Evidence Generation for Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026

Same journal

Weekly and Biweekly Treatment With Bofanglutide Versus Semaglutide in Chinese Patients With Type 2 Diabetes : A Phase 2b Randomized Clinical Trial.

Annals of internal medicine·2026

Same journal

Grappling with GLP-1 prescribing.

Annals of internal medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 5, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

Clinical inertia.

L S Phillips¹, W T Branch, C B Cook

¹Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA. medlsp@emory.edu

Annals of Internal Medicine

|November 6, 2001

Summary

This summary is machine-generated.

Clinical inertia, the failure to intensify therapy for conditions like hypertension, dyslipidemia, and diabetes, hinders effective patient care. Overcoming this requires revised medical education and practice systems focused on achieving therapeutic targets.

More Related Videos

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence

Published on: February 23, 2021

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes

Published on: February 14, 2025

Related Experiment Videos

Last Updated: May 5, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence

Published on: February 23, 2021

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes

Published on: February 14, 2025

Area of Science:

Medical Education
Preventive Medicine
Health Management

Background:

Modern healthcare increasingly manages asymptomatic chronic conditions like hypertension, dyslipidemia, and diabetes.
Treatment decisions for these conditions often rely on abnormal biomarker values rather than patient symptoms.
Clinical inertia, the failure to initiate or intensify therapy, presents a significant barrier to effective management.

Purpose of the Study:

To identify the causes of clinical inertia in managing chronic diseases.
To propose strategies for overcoming clinical inertia in medical practice.
To emphasize the importance of treating to therapeutic targets for better health outcomes.

Main Methods:

The study identifies clinical inertia as a key problem in managing asymptomatic chronic diseases.
It analyzes the root causes of clinical inertia, including overestimation of care and avoidance of therapy intensification.
It proposes educational and practice-based strategies to address these issues.

Main Results:

Clinical inertia stems from overestimating care, using "soft" reasons to delay treatment intensification, and inadequate education or practice organization.
Effective management requires treating to specific therapeutic targets, not just symptom relief.
Physicians need structured practice systems with reminders and feedback to ensure guideline-adherent care.

Conclusions:

Overcoming clinical inertia is crucial for managing chronic diseases like hypertension, dyslipidemia, and diabetes.
Revised medical education must emphasize treating to therapeutic targets and practical management strategies.
Implementing practice-based systems, including reminders and performance feedback, is essential for physicians to achieve therapeutic goals.