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[Initial subretinal localization of acute myeloblastic leukemia (AML5) recurrence]
S Le Gall1, S François, N Urier
1Service d'Hématologie, CHU Angers, Paris.
Background:
Reduced visual acuity in patients with acute leucemia can result from many causes including an ocular localization.
Case Report:
A patient previously treated for acute myeloblastic leucemia-5 (AML5) developed bilateral vision impairment related to a subretinal localization of the leucemia. Meningeal and bone marrow relapse followed. The subretinal localization responded only to massive systemic steroid treatment.
Discussion:
Although asymptomatic, ocular localizations are frequent in leucemia. Their prognostic impact depends on the ocular structure involved and on the chronology of onset--early or late in the leucemia course. The underlying pathophysiological mechanism of ocular involvement remains unexplained but hyperleucocytosis at presentation may be a risk factor and would justify at least systematic specialized examinations and discussion of prophylactic treatment.