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Effect of the isolated left bundle branch block on systolic and diastolic functions of left ventricle

K Ozdemir1, B B Altunkeser, G Daniş

  • 1Department of Cardiology, Faculty of Medicine, Selçuk University, Konya, Turkey. kurt33@hotmail.com

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|November 7, 2001
PubMed

Insights

Left bundle branch block (LBBB) significantly impairs left ventricular (LV) systolic and diastolic functions, evidenced by elevated myocardial performance index (MPI) and end-diastolic pressure. These findings highlight LBBB as a cause of substantial cardiac dysfunction.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Echocardiography

Background:

  • Left bundle branch block (LBBB) is a common conduction abnormality.
  • Its detailed effects on left ventricular (LV) systolic and diastolic functions require further investigation.

Purpose of the Study:

  • To evaluate the impact of isolated LBBB on LV systolic and diastolic functions.
  • To compare cardiac function parameters between patients with LBBB and healthy controls.

Main Methods:

  • Echocardiography was performed on 45 LBBB patients (Group I) and 65 controls (Group II).
  • Key parameters measured included isovolumetric relaxation time (IRT), isovolumetric contraction time (ICT), ejection time (ET), and myocardial performance index (MPI).
  • LV end-diastolic pressure was assessed via coronary angiography in a subset of patients.

Main Results:

  • LBBB patients exhibited increased LV end-systolic diameter and reduced ejection fraction.
  • Significant alterations in diastolic function, including prolonged IRT and ICT, and shortened LV diastolic period and ET were observed.
  • MPI was markedly elevated (0.89 vs 0.40) and LV end-diastolic pressure was higher (14 vs 10 mmHg) in the LBBB group.

Conclusions:

  • Isolated LBBB leads to significant deterioration of LV systolic and diastolic functions.
  • Elevated LV MPI and end-diastolic pressure in LBBB patients correlate with conventional echocardiographic findings.
  • LBBB is associated with substantial impairment of overall left ventricular performance.
Abstract

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